Coadaptive Stability of Interfering Particles with HIV-1 When There Is an Evolutionary Conflict
نویسندگان
چکیده
منابع مشابه
Reply to "Coadaptive stability of interfering particles with HIV-1 when there is an evolutionary conflict".
HIV-1 evolution is a fundamental challenge for any therapeutic intervention. Rouzine and Weinberger (1) presented a mathematical analysis of the evolutionary stability of proposed therapies that would use engineered defective interfering particles (DIPs) to treat HIV-1 patients. Their analyses are illuminating, particularly in highlighting the importance of multiple DIP infections of a cell and...
متن کاملCoadaptive Stability of Interfering Particles with HIV-1 When There Is an Evolutionary Conflict
HIV-1 evolution is a fundamental challenge for any therapeutic intervention. Rouzine and Weinberger (1) presented a mathematical analysis of the evolutionary stability of proposed therapies that would use engineered defective interfering particles (DIPs) to treat HIV-1 patients. Their analyses are illuminating, particularly in highlighting the importance of multiple DIP infections of a cell and...
متن کاملDesign requirements for interfering particles to maintain coadaptive stability with HIV-1.
Defective interfering particles (DIPs) are viral deletion mutants lacking essential transacting or packaging elements and must be complemented by wild-type virus to propagate. DIPs transmit through human populations, replicating at the expense of the wild-type virus and acting as molecular parasites of viruses. Consequently, engineered DIPs have been proposed as therapies for a number of diseas...
متن کاملAdaptive HIV-1 evolutionary trajectories are constrained by protein stability
Despite the use of combination antiretroviral drugs for the treatment of HIV-1 infection, the emergence of drug resistance remains a problem. Resistance may be conferred either by a single mutation or a concerted set of mutations. The involvement of multiple mutations can arise due to interactions between sites in the amino acid sequence as a consequence of the need to maintain protein structur...
متن کاملUtility When There Is a Preference for Beliefs: a Behavioral Model of Political Conflict
We consider the case where individuals derive utility from feeling good about themselves and their group, but where the satisfaction of such preferences may come at a cost. In other contexts, what people want to believe is considered irrational, but in our model, these are preferences like any other. Equilibrium subjective beliefs concerning whether one’s group has acted appropriately are endog...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Virology
سال: 2013
ISSN: 0022-538X
DOI: 10.1128/jvi.00705-13